Cell Culture
Tip: Improve Cell Adhesion for Microscopy (Mock Tip)
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Dr. Evelyn Reed
Institute for Advanced Science
For tricky cell lines that lift off during staining, coat your glass coverslips with Poly-L-Lysine (0.1 mg/mL in water) for 1 hour at room temperature before seeding. This provides a positively charged surface that promotes adhesion. Remember to wash with sterile water before adding cells.
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SharedMarch 21st, 2026